Загрузка...
The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein
Therapeutic immunoglobulin G (IgG) antibodies have comparatively long half-lives because the neonatal Fc receptor (FcRn) binds to the IgG Fc at acidic pH in the endosome and protects IgG from degradation. To further prolong the half-lives, amino acid-substituted antibodies having high affinity to Fc...
Сохранить в:
| Опубликовано в: : | MAbs |
|---|---|
| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2021
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8158039/ https://ncbi.nlm.nih.gov/pubmed/34030575 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2021.1923366 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|