Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling

Background: Liver fibrosis is characterized by extensive deposition of extracellular matrix (ECM) components in the liver. RCAN1 (regulator of calcineurin 1), an endogenous inhibitor of calcineurin (CaN), is required for ECM synthesis during hypertrophy of various organs. However, the functional rol...

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Udgivet i:Theranostics
Main Authors: Pan, Xue-yin, You, Hong-mei, Wang, Ling, Bi, Yi-hui, Yang, Yang, Meng, Hong-wu, Meng, Xiao-ming, Ma, Tao-tao, Huang, Cheng, Li, Jun
Format: Artigo
Sprog:Inglês
Udgivet: Ivyspring International Publisher 2019
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599664/
https://ncbi.nlm.nih.gov/pubmed/31285763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.32710
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