Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling

Background: Liver fibrosis is characterized by extensive deposition of extracellular matrix (ECM) components in the liver. RCAN1 (regulator of calcineurin 1), an endogenous inhibitor of calcineurin (CaN), is required for ECM synthesis during hypertrophy of various organs. However, the functional rol...

Full description

Saved in:
Bibliographic Details
Published in:Theranostics
Main Authors: Pan, Xue-yin, You, Hong-mei, Wang, Ling, Bi, Yi-hui, Yang, Yang, Meng, Hong-wu, Meng, Xiao-ming, Ma, Tao-tao, Huang, Cheng, Li, Jun
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2019
Subjects:
Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599664/
https://ncbi.nlm.nih.gov/pubmed/31285763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.32710
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items