Methylation of RCAN1.4 mediated by DNMT1 and DNMT3b enhances hepatic stellate cell activation and liver fibrogenesis through Calcineurin/NFAT3 signaling

Background: Liver fibrosis is characterized by extensive deposition of extracellular matrix (ECM) components in the liver. RCAN1 (regulator of calcineurin 1), an endogenous inhibitor of calcineurin (CaN), is required for ECM synthesis during hypertrophy of various organs. However, the functional rol...

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Foilsithe in:Theranostics
Main Authors: Pan, Xue-yin, You, Hong-mei, Wang, Ling, Bi, Yi-hui, Yang, Yang, Meng, Hong-wu, Meng, Xiao-ming, Ma, Tao-tao, Huang, Cheng, Li, Jun
Formáid: Artigo
Teanga:Inglês
Foilsithe: Ivyspring International Publisher 2019
Ábhair:
Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599664/
https://ncbi.nlm.nih.gov/pubmed/31285763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.32710
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