The role of Na(v)1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes

Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic neuropathy. Methods: Scratching behavior,...

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Dades bibliogràfiques
Publicat a:Theranostics
Autors principals: Cheng, Ruo-Xiao, Feng, Yu, Liu, Di, Wang, Zhi-Hong, Zhang, Jiang-Tao, Chen, Li-Hua, Su, Cun-Jin, Wang, Bing, Huang, Ya, Ji, Ru-Rong, Hu, Ji, Liu, Tong
Format: Artigo
Idioma:Inglês
Publicat: Ivyspring International Publisher 2019
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599654/
https://ncbi.nlm.nih.gov/pubmed/31285762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36077
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