The role of Na(v)1.7 and methylglyoxal-mediated activation of TRPA1 in itch and hypoalgesia in a murine model of type 1 diabetes

Methylglyoxal (MGO), an endogenous reactive carbonyl compound, plays a key role in the pathogenesis of diabetic neuropathy. The aim of this study is to investigate the role of MGO in diabetic itch and hypoalgesia, two common symptoms associated with diabetic neuropathy. Methods: Scratching behavior,...

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Enregistré dans:
Détails bibliographiques
Publié dans:Theranostics
Auteurs principaux: Cheng, Ruo-Xiao, Feng, Yu, Liu, Di, Wang, Zhi-Hong, Zhang, Jiang-Tao, Chen, Li-Hua, Su, Cun-Jin, Wang, Bing, Huang, Ya, Ji, Ru-Rong, Hu, Ji, Liu, Tong
Format: Artigo
Langue:Inglês
Publié: Ivyspring International Publisher 2019
Sujets:
Research Paper
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6599654/
https://ncbi.nlm.nih.gov/pubmed/31285762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.36077
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