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Generating viable mice with heritable embryonically lethal mutations using the CRISPR-Cas9 system in two-cell embryos
A substantial number of mouse genes, about 25%, are embryonically lethal when knocked out. Using current genetic tools, such as the CRISPR-Cas9 system, it is difficult—or even impossible—to produce viable mice with heritable embryonically lethal mutations. Here, we establish a one-step method for mi...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6599060/ https://ncbi.nlm.nih.gov/pubmed/31253768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10748-2 |
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