In vitro genotoxicity of nitroimidazoles as a tool in the search of new trypanocidal agents

BACKGROUND: Only benznidazole (Bnz) (1) and nifurtimox (Nfx) (2) are licensed for the treatment of Chagas disease although their safety and efficacy profile are far from ideal. Farmanguinhos from Fiocruz has developed seven nitroimidazole compounds (4-10) analogs of megazol (3). OBJECTIVES: To evalu...

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Enregistré dans:
Détails bibliographiques
Publié dans:Mem Inst Oswaldo Cruz
Auteurs principaux: Von Trompowsky, Ana Claudia Manoel, Conde, Taline Ramos, Lemos, Renata Calil, Quaresma, Bruna Maria CS, Pitombeira, Marcelly Cristina SR, de Carvalho, Alcione Silva, Boechat, Núbia, Salomão, Kelly, de Castro, Solange Lisboa, Zamith, Helena Pereira da Silva
Format: Artigo
Langue:Inglês
Publié: Instituto Oswaldo Cruz, Ministério da Saúde 2019
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598759/
https://ncbi.nlm.nih.gov/pubmed/31271593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1590/0074-02760190017
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