Choroid Plexus Acts as Gatekeeper for TREM2, Abnormal Accumulation of ApoE, and Fibrillary Tau in Alzheimer’s Disease and in Down Syndrome Dementia

BACKGROUND: Genetic factors that influence Alzheimer’s disease (AD) risk include mutations in TREM2 and allelic variants of Apolipoprotein E, influencing AD pathology in the general population and in Down syndrome (DS). Evidence shows that dysfunction of the choroid plexus may compromise the blood-c...

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發表在:J Alzheimers Dis
Main Authors: Raha-Chowdhury, Ruma, Henderson, James W., Raha, Animesh Alexander, Vuono, Romina, Bickerton, Anastasia, Jones, Elizabeth, Fincham, Robert, Allinson, Kieren, Holland, Anthony, Zaman, Shahid H.
格式: Artigo
語言:Inglês
出版: IOS Press 2019
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Researh Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6598012/
https://ncbi.nlm.nih.gov/pubmed/30909239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-181179
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