Erythromyeloid-Derived TREM2: A Major Determinant of Alzheimer’s Disease Pathology in Down Syndrome

BACKGROUND: Down syndrome (DS; trisomy 21) individuals have a spectrum of hematopoietic and neuronal dysfunctions and by the time they reach the age of 40 years, almost all develop Alzheimer’s disease (AD) neuropathology which includes senile plaques and neurofibrillary tangles. Inflammation and inn...

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Detalhes bibliográficos
Publicado no:J Alzheimers Dis
Main Authors: Raha-Chowdhury, Ruma, Henderson, James W., Raha, Animesh Alexander, Stott, Simon R.W., Vuono, Romina, Foscarin, Simona, Wilson, Liam, Annus, Tiina, Fincham, Robert, Allinson, Kieren, Devalia, Vinod, Friedland, Robert P., Holland, Anthony, Zaman, Shahid H.
Formato: Artigo
Idioma:Inglês
Publicado em: IOS Press 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5817909/
https://ncbi.nlm.nih.gov/pubmed/29278889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-170814
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