E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity

Parkinson's disease (PD) is one of the most common neurodegenerative disorders, and both genetic and histopathological evidence have implicated the ubiquitous presynaptic protein α-synuclein (αSyn) in its pathogenesis. Recent work has investigated how disrupting αSyn's interaction with mem...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Rovere, Matteo, Powers, Alex E., Jiang, Haiyang, Pitino, Julia C., Fonseca-Ornelas, Luis, Patel, Dushyant S., Achille, Alessandro, Langen, Ralf, Varkey, Jobin, Bartels, Tim
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2019
Aiheet:
Molecular Bases of Disease
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597829/
https://ncbi.nlm.nih.gov/pubmed/31048377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006551
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