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Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation

α-Synuclein (αS) is a protein with multiple conformations and interactions. Natively unfolded in solution, αS accumulates as amyloid in neurological tissue in Parkinson disease and interacts with membranes under both physiological and pathological conditions. Here, we used cryoelectron microscopy in...

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Detalhes bibliográficos
Main Authors: Mizuno, Naoko, Varkey, Jobin, Kegulian, Natalie C., Hegde, Balachandra G., Cheng, Naiqian, Langen, Ralf, Steven, Alasdair C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3436199/
https://ncbi.nlm.nih.gov/pubmed/22767608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.365817
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