α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils

Parkinson disease and other progressive neurodegenerative conditions are characterized by the intracerebral presence of Lewy bodies, containing amyloid fibrils of α-synuclein. We used cryo-electron microscopy and scanning transmission electron microscopy (STEM) to study in vitro-assembled fibrils. T...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Dearborn, Altaira D., Wall, Joseph S., Cheng, Naiqian, Heymann, J. Bernard, Kajava, Andrey V., Varkey, Jobin, Langen, Ralf, Steven, Alasdair C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2016
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4732214/
https://ncbi.nlm.nih.gov/pubmed/26644467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.698787
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