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C-terminal α-synuclein truncations are linked to cysteine cathepsin activity in Parkinson's disease
A pathological feature of Parkinson's disease (PD) is Lewy bodies (LBs) composed of α-synuclein (α-syn) amyloid fibrils. α-Syn is a 140 amino acids–long protein, but truncated α-syn is enriched in LBs. The proteolytic processes that generate these truncations are not well-understood. On the bas...
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| Udgivet i: | J Biol Chem |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6597809/ https://ncbi.nlm.nih.gov/pubmed/31092553 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.008930 |
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