α-Synuclein Interacts with Glucocerebrosidase Providing a Molecular Link between Parkinson and Gaucher Diseases

The presynaptic protein α-synuclein (α-syn), particularly in its amyloid form, is widely recognized for its involvement in Parkinson disease (PD). Recent genetic studies reveal that mutations in the gene GBA are the most widespread genetic risk factor for parkinsonism identified to date. GBA encodes...

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Bibliografske podrobnosti
Main Authors: Yap, Thai Leong, Gruschus, James M., Velayati, Arash, Westbroek, Wendy, Goldin, Ehud, Moaven, Nima, Sidransky, Ellen, Lee, Jennifer C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Protein Structure and Folding
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151053/
https://ncbi.nlm.nih.gov/pubmed/21653695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.237859
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