Endothelial plasminogen activator inhibitor-1 blocks the intrinsic pathway of coagulation, inducing the clearance and degradation of factor XIa.

OBJECTIVE: Activation of coagulation factor (F) XI by activated coagulation FXII (FXIIa) is a prothrombotic process. The endothelium is known to play an antithrombotic role by limiting thrombin generation and platelet activation. It is unknown whether the antithrombotic role of the endothelium inclu...

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Veröffentlicht in:Arterioscler Thromb Vasc Biol
Hauptverfasser: Puy, Cristina, Ngo, Anh T.P., Pang, Jiaqing, Keshari, Ravi S., Hagen, Matthew W., Hinds, Monica T, Gailani, David, Gruber, András, Lupu, Florea, McCarty, Owen J. T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597189/
https://ncbi.nlm.nih.gov/pubmed/31242030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.119.312619
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