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Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell

EphA2 overexpression is invariably associated with poor prognosis and development of aggressive metastatic cancers in pancreatic, prostate, lung, ovarian, and breast cancers and melanoma. Recent efforts from our laboratories identified a number of agonistic peptides targeting the ligand-binding doma...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Gambini, Luca, Salem, Ahmed F., Udompholkul, Parima, Tan, Xiao-Feng, Baggio, Carlo, Shah, Neh, Aronson, Alexander, Song, Jikui, Pellecchia, Maurizio
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6597003/
https://ncbi.nlm.nih.gov/pubmed/30110533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00556
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