Synaptotoxicity in Alzheimer's Disease Involved a Dysregulation of Actin Cytoskeleton Dynamics through Cofilin 1 Phosphorylation

Amyloid-β (Aβ) drives the synaptic impairment and dendritic spine loss characteristic of Alzheimer's disease (AD), but how Aβ affects the actin cytoskeleton remains unknown and contentious. The actin-binding protein, cofilin-1 (cof1), is a major regulator of actin dynamics in dendritic spines,...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Rush, Travis, Martinez-Hernandez, Jose, Dollmeyer, Marc, Frandemiche, Marie Lise, Borel, Eve, Boisseau, Sylvie, Jacquier-Sarlin, Muriel, Buisson, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596209/
https://ncbi.nlm.nih.gov/pubmed/30341179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1409-18.2018
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