TRPA1 channels promote astrocytic Ca(2+) hyperactivity and synaptic dysfunction mediated by oligomeric forms of amyloid-β peptide

BACKGROUND: Excessive synaptic loss is thought to be one of the earliest events in Alzheimer’s disease (AD). However, the key mechanisms that maintain plasticity of synapses during adulthood or initiate synapse dysfunction in AD remain unknown. Recent studies suggest that astrocytes contribute to fu...

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Detalhes bibliográficos
Publicado no:Mol Neurodegener
Main Authors: Bosson, Anthony, Paumier, Adrien, Boisseau, Sylvie, Jacquier-Sarlin, Muriel, Buisson, Alain, Albrieux, Mireille
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501536/
https://ncbi.nlm.nih.gov/pubmed/28683776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0194-8
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