S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit

Elevated iron deposition has been reported in Parkinson's disease (PD). However, the route of iron uptake leading to high deposition in the substantia nigra is unresolved. Here, we show a mechanism in enhanced Fe(2+) uptake via S-nitrosylation of divalent metal transporter 1 (DMT1). While DMT1...

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Publicado no:J Neurosci
Main Authors: Liu, Chao, Zhang, Cheng-Wu, Lo, Shun Qiang, Ang, Seok Ting, Chew, Katherine Chee Meng, Yu, Dejie, Chai, Bing Han, Tan, Bobby, Tsang, Fai, Tai, Yee Kit, Tan, Bryce Wei Quan, Liang, Mui Cheng, Tan, Hwee Tong, Tang, Jia Ying, Lai, Mitchell Kim Peng, Chua, John Jia En, Chung, Maxey Ching Ming, Khanna, Sanjay, Lim, Kah-Leong, Soong, Tuck Wah
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596170/
https://ncbi.nlm.nih.gov/pubmed/30104344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3262-17.2018
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