S-Nitrosylation of Divalent Metal Transporter 1 Enhances Iron Uptake to Mediate Loss of Dopaminergic Neurons and Motoric Deficit

Elevated iron deposition has been reported in Parkinson's disease (PD). However, the route of iron uptake leading to high deposition in the substantia nigra is unresolved. Here, we show a mechanism in enhanced Fe(2+) uptake via S-nitrosylation of divalent metal transporter 1 (DMT1). While DMT1...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Liu, Chao, Zhang, Cheng-Wu, Lo, Shun Qiang, Ang, Seok Ting, Chew, Katherine Chee Meng, Yu, Dejie, Chai, Bing Han, Tan, Bobby, Tsang, Fai, Tai, Yee Kit, Tan, Bryce Wei Quan, Liang, Mui Cheng, Tan, Hwee Tong, Tang, Jia Ying, Lai, Mitchell Kim Peng, Chua, John Jia En, Chung, Maxey Ching Ming, Khanna, Sanjay, Lim, Kah-Leong, Soong, Tuck Wah
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2018
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596170/
https://ncbi.nlm.nih.gov/pubmed/30104344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3262-17.2018
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