Discovery of (aza)indole derivatives as novel respiratory syncytial virus fusion inhibitors

A new class of indole derivatives (3) have been identified as potent RSV fusion inhibitors. SAR exploration revealed that 5-Cl and the sulfonyl side chain of the indole scaffold are crucial for anti-RSV activity. Further optimization led to the discovery of a cyclic sulfone (8i) with 2 nM anti-RSV a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Medchemcomm
Prif Awduron: Zheng, Xiufang, Liang, Chungen, Wang, Lisha, Miao, Kun, Wang, Baoxia, Zhang, Weixing, Chen, Dongdong, Wu, Guolong, Zhu, Wei, Guo, Lei, Feng, Song, Gao, Lu, Shen, Hong C., Yun, Hongying
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Royal Society of Chemistry 2019
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596086/
https://ncbi.nlm.nih.gov/pubmed/31303995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c9md00178f
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