Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus

A series of five benzimidazole-based compounds were identified using a machine learning algorithm as potential inhibitors of the respiratory syncytial virus (RSV) fusion protein. These compounds were synthesized, and compound 2 in particular exhibited excellent in vitro potency with an EC(50) value...

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Publicat a:ACS Infect Dis
Autors principals: Pribut, Nicole, Kaiser, Thomas M., Wilson, Robert J., Jecs, Edgars, Dentmon, Zackery W., Pelly, Stephen C., Sharma, Savita, Bartsch, Perry W., Burger, Pieter B., Hwang, Soyon S., Le, Thalia, Sourimant, Julien, Yoon, Jeong-Joong, Plemper, Richard K., Liotta, Dennis C.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7456560/
https://ncbi.nlm.nih.gov/pubmed/32275393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsinfecdis.9b00524
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