Discovery of a Potent Dual Inhibitor of Wild-Type and Mutant Respiratory Syncytial Virus Fusion Proteins

[Image: see text] A novel series of macrocyclic pyrazolo[1,5-a]pyrimidine derivatives as respiratory syncytial virus (RSV) fusion glycoprotein (F protein) inhibitors were designed and synthesized based on docking studies of acyclic inhibitors. This effort resulted in the discovery of several macrocy...

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Veröffentlicht in:ACS Med Chem Lett
Hauptverfasser: Yamaguchi-Sasaki, Toru, Tokura, Seiken, Ogata, Yuya, Kawaguchi, Takanori, Sugaya, Yutaka, Takahashi, Ryo, Iwakiri, Kanako, Abe-Kumasaka, Tomoko, Yoshida, Ippei, Arikawa, Kaho, Sugiyama, Hiroyuki, Kanuma, Kosuke
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2020
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294717/
https://ncbi.nlm.nih.gov/pubmed/32550994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.0c00008
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