Sustained Expression of Negative Regulators of Myelination Protects Schwann Cells from Dysmyelination in a Charcot–Marie–Tooth 1B Mouse Model

Schwann cell differentiation and myelination in the PNS are the result of fine-tuning of positive and negative transcriptional regulators. As myelination starts, negative regulators are downregulated, whereas positive ones are upregulated. Fully differentiated Schwann cells maintain an extraordinary...

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Pubblicato in:J Neurosci
Autori principali: Florio, Francesca, Ferri, Cinzia, Scapin, Cristina, Feltri, M. Laura, Wrabetz, Lawrence, D'Antonio, Maurizio
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2018
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Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6596005/
https://ncbi.nlm.nih.gov/pubmed/29610440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0201-18.2018
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