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Perpetrator effects of ciclosporin (P‐glycoprotein inhibitor) and its combination with fluconazole (CYP3A inhibitor) on the pharmacokinetics of rivaroxaban in healthy volunteers
AIMS: Rivaroxaban exposure is considerably increased by drugs that are combined P‐glycoprotein (P‐gp) and strong cytochrome P450 (CYP) 3A inhibitors (e.g. ketoconazole). The aim of the present study was to investigate the effects of the potent P‐gp inhibitor ciclosporin and its combination with the...
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| Udgivet i: | Br J Clin Pharmacol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595291/ https://ncbi.nlm.nih.gov/pubmed/30912163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13934 |
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