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Application of a microdosed cocktail of 3 oral factor Xa inhibitors to study drug–drug interactions with different perpetrator drugs

AIMS: Using 3 different perpetrators the impact of voriconazole, cobicistat and rifampicin (single dose), we evaluated the suitability of a microdose cocktail of factor Xa inhibitors (FXaI; rivaroxaban, apixaban and edoxaban; 100 μg in total) to study drug–drug interactions. METHODS: Three cohorts o...

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書目詳細資料
發表在:Br J Clin Pharmacol
Main Authors: Mikus, Gerd, Foerster, Kathrin I., Schaumaeker, Marlene, Lehmann, Marie‐Louise, Burhenne, Jürgen, Haefeli, Walter E.
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2020
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7373712/
https://ncbi.nlm.nih.gov/pubmed/32159869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.14277
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