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Perpetrator effects of ciclosporin (P‐glycoprotein inhibitor) and its combination with fluconazole (CYP3A inhibitor) on the pharmacokinetics of rivaroxaban in healthy volunteers
AIMS: Rivaroxaban exposure is considerably increased by drugs that are combined P‐glycoprotein (P‐gp) and strong cytochrome P450 (CYP) 3A inhibitors (e.g. ketoconazole). The aim of the present study was to investigate the effects of the potent P‐gp inhibitor ciclosporin and its combination with the...
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| Publié dans: | Br J Clin Pharmacol |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
John Wiley and Sons Inc.
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6595291/ https://ncbi.nlm.nih.gov/pubmed/30912163 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13934 |
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