GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients

GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) within the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1-bound LPL is essential for the margination of triglyceride-rich lipoproteins (TRLs) along capillaries, allowing the lipolyti...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Hu, Xuchen, Matsumoto, Ken, Jung, Rachel S, Weston, Thomas A, Heizer, Patrick J, He, Cuiwen, Sandoval, Norma P, Allan, Christopher M, Tu, Yiping, Vinters, Harry V, Liau, Linda M, Ellison, Rochelle M, Morales, Jazmin E, Baufeld, Lynn J, Bayley, Nicholas A, He, Liqun, Betsholtz, Christer, Beigneux, Anne P, Nathanson, David A, Gerhardt, Holger, Young, Stephen G, Fong, Loren G, Jiang, Haibo
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Biochemistry and Chemical Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594755/
https://ncbi.nlm.nih.gov/pubmed/31169500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.47178
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