Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice

Perfluorooctanoic acid is a ligand for peroxisome proliferator-activated receptor (PPARα). Ammonium perfluorooctanoate (APFO) at 0.1 and 0.3 mg/kg doses activated mouse PPARα, but not human PPARα. This study aimed to clarify whether milligram-order APFO can activate human PPARα, and the receptor is...

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Detalhes bibliográficos
Publicado no:Arch Toxicol
Main Authors: Nakagawa, Tomohiko, Ramdhan, Doni Hikmat, Tanaka, Naoki, Naito, Hisao, Tamada, Hazuki, Ito, Yuki, Li, Yufei, Hayashi, Yumi, Yamagishi, Nozomi, Yanagiba, Yukie, Aoyama, Toshifumi, Gonzalez, Frank J., Nakajima, Tamie
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594146/
https://ncbi.nlm.nih.gov/pubmed/21499893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-011-0704-3
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