Plasticizers May Activate Human Hepatic Peroxisome Proliferator-Activated Receptor α Less Than That of a Mouse but May Activate Constitutive Androstane Receptor in Liver

Dibutylphthalate (DBP), di(2-ethylhexyl)phthalate (DEHP), and di(2-ethylhexyl)adipate (DEHA) are used as plasticizers. Their metabolites activate peroxisome proliferator-activated receptor (PPAR) α, which may be related to their toxicities. However, species differences in the receptor functions betw...

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Hlavní autoři: Ito, Yuki, Nakamura, Toshiki, Yanagiba, Yukie, Ramdhan, Doni Hikmat, Yamagishi, Nozomi, Naito, Hisao, Kamijima, Michihiro, Gonzalez, Frank J., Nakajima, Tamie
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3388330/
https://ncbi.nlm.nih.gov/pubmed/22792086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/201284
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