Differential Response to Trichloroethylene-Induced Hepatosteatosis in Wild-Type and PPARα-Humanized Mice

BACKGROUND: Trichloroacetic acid, an oxidative metabolite of trichloroethylene (TRI), is a ligand of the peroxisome proliferator-activated receptor α (PPAR) α, which is involved in lipid homeostasis and anti-inflammation. OBJECTIVE: We examined the role of mouse and human PPARα in TRI-induced hepati...

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Detalhes bibliográficos
Main Authors: Ramdhan, Doni Hikmat, Kamijima, Michihiro, Wang, Dong, Ito, Yuki, Naito, Hisao, Yanagiba, Yukie, Hayashi, Yumi, Tanaka, Naoki, Aoyama, Toshifumi, Gonzalez, Frank J., Nakajima, Tamie
Formato: Artigo
Idioma:Inglês
Publicado em: National Institute of Environmental Health Sciences 2010
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Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2974693/
https://ncbi.nlm.nih.gov/pubmed/20709644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1289/ehp.1001928
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