The Tat inhibitor didehydro-cortistatin A suppresses SIV replication and reactivation

The HIV-1 transactivation protein (Tat) binds the HIV mRNA transactivation responsive element (TAR), regulating transcription and reactivation from latency. Drugs against Tat are unfortunately not clinically available. We reported that didehydro-cortistatin A (dCA) inhibits HIV-1 Tat activity. In hu...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Mediouni, Sonia, Kessing, Cari F., Jablonski, Joseph A., Thenin-Houssier, Suzie, Clementz, Mark, Kovach, Melia D., Mousseau, Guillaume, de Vera, Ian Mitchelle S., Li, Chuan, Kojetin, Douglas J., Evans, David T., Valente, Susana T.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593873/
https://ncbi.nlm.nih.gov/pubmed/31021670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801165R
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