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Tat inhibition by didehydro-Cortistatin A promotes heterochromatin formation at the HIV-1 long terminal repeat

BACKGROUND: Transcription from the integrated HIV-1 promoter is directly governed by its chromatin environment, and the nucleosome-1 downstream from the transcription start site directly impedes transcription from the HIV-1 promoter. The HIV-1 Tat protein regulates the passage from viral latency to...

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Detalhes bibliográficos
Publicado no:Epigenetics Chromatin
Main Authors: Li, Chuan, Mousseau, Guillaume, Valente, Susana T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6466689/
https://ncbi.nlm.nih.gov/pubmed/30992052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13072-019-0267-8
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