Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

PURPOSE/OBJECTIVE: Radiotherapy (RT) induces an immunogenic antitumor response, but also some immunosuppressive barriers. It remains unclear how different fractionation protocols can modulate the immune microenvironment. Clinical studies are ongoing to evaluate immune checkpoint inhibitors (ICI) in...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Grapin, Mathieu, Richard, Corentin, Limagne, Emeric, Boidot, Romain, Morgand, Véronique, Bertaut, Aurélie, Derangere, Valentin, Laurent, Pierre-Antoine, Thibaudin, Marion, Fumet, Jean David, Crehange, Gilles, Ghiringhelli, François, Mirjolet, Céline
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593525/
https://ncbi.nlm.nih.gov/pubmed/31238970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0634-9
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