Optimized fractionated radiotherapy with anti-PD-L1 and anti-TIGIT: a promising new combination

PURPOSE/OBJECTIVE: Radiotherapy (RT) induces an immunogenic antitumor response, but also some immunosuppressive barriers. It remains unclear how different fractionation protocols can modulate the immune microenvironment. Clinical studies are ongoing to evaluate immune checkpoint inhibitors (ICI) in...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Grapin, Mathieu, Richard, Corentin, Limagne, Emeric, Boidot, Romain, Morgand, Véronique, Bertaut, Aurélie, Derangere, Valentin, Laurent, Pierre-Antoine, Thibaudin, Marion, Fumet, Jean David, Crehange, Gilles, Ghiringhelli, François, Mirjolet, Céline
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593525/
https://ncbi.nlm.nih.gov/pubmed/31238970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0634-9
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