Precision medicine phase II study evaluating the efficacy of a double immunotherapy by durvalumab and tremelimumab combined with olaparib in patients with solid cancers and carriers of homologous recombination repair genes mutation in response or stable after olaparib treatment

BACKGROUND: Tumors with deficient homologous repair are sensitive to PARP inhibitors such as olaparib which is known to have immunogenic properties. Durvalumab (D) is a human monoclonal antibody (mAb) which inhibits binding of programmed cell death ligand 1 (PD-L1) to its receptor. Tremelimumab (T)...

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Vydáno v:BMC Cancer
Hlavní autoři: Fumet, Jean-David, Limagne, Emeric, Thibaudin, Marion, Truntzer, Caroline, Bertaut, Aurélie, Rederstorff, Emilie, Ghiringhelli, Francois
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
Témata:
Study Protocol
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7418426/
https://ncbi.nlm.nih.gov/pubmed/32778095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07253-x
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