Profiling interactions of vaborbactam with metallo-β-lactamases

β-Lactams are the most successful antibacterials, yet their use is threatened by resistance, importantly as caused by β-lactamases. β-Lactamases fall into two mechanistic groups: the serine β-lactamases that utilise a covalent acyl-enzyme mechanism and the metallo β-lactamases that utilise a zinc-bo...

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Vydáno v:Bioorg Med Chem Lett
Hlavní autoři: Langley, Gareth W., Cain, Ricky, Tyrrell, Jonathan M., Hinchliffe, Philip, Calvopiña, Karina, Tooke, Catherine L., Widlake, Emma, Dowson, Christopher G., Spencer, James, Walsh, Timothy R., Schofield, Christopher J., Brem, Jürgen
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier Science Ltd 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6593178/
https://ncbi.nlm.nih.gov/pubmed/31171422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2019.05.031
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