Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Defining the metabolic programs that underlie stem cell maintenance will be essential for developing strategies to manipulate stem cell capacity. Mammalian hematopoietic stem cells (HSCs) maintain cell cycle quiescence in a hypoxic microenvironment. It has been proposed that HSCs exhibit a distinct...

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Udgivet i:Cell Stem Cell
Main Authors: Takubo, Keiyo, Nagamatsu, Go, Kobayashi, Chiharu I., Nakamura-Ishizu, Ayako, Kobayashi, Hiroshi, Ikeda, Eiji, Goda, Nobuhito, Rahimi, Yasmeen, Johnson, Randall S., Soga, Tomoyoshi, Hirao, Atsushi, Suematsu, Makoto, Suda, Toshio
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592822/
https://ncbi.nlm.nih.gov/pubmed/23290136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.10.011
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