Massive antibody discovery used to probe structure–function relationships of the essential outer membrane protein LptD

Outer membrane proteins (OMPs) in Gram-negative bacteria dictate permeability of metabolites, antibiotics, and toxins. Elucidating the structure-function relationships governing OMPs within native membrane environments remains challenging. We constructed a diverse library of >3000 monoclonal anti...

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Pubblicato in:eLife
Autori principali: Storek, Kelly M, Chan, Joyce, Vij, Rajesh, Chiang, Nancy, Lin, Zhonghua, Bevers, Jack, Koth, Christopher M, Vernes, Jean-Michel, Meng, Y Gloria, Yin, JianPing, Wallweber, Heidi, Dalmas, Olivier, Shriver, Stephanie, Tam, Christine, Schneider, Kellen, Seshasayee, Dhaya, Nakamura, Gerald, Smith, Peter A, Payandeh, Jian, Koerber, James T, Comps-Agrar, Laetitia, Rutherford, Steven T
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2019
Soggetti:
Microbiology and Infectious Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592684/
https://ncbi.nlm.nih.gov/pubmed/31237236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46258
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