A targeted boost-and-sort immunization strategy using Escherichia coli BamA identifies rare growth inhibitory antibodies

Outer membrane proteins (OMPs) in Gram-negative bacteria are essential for a number of cellular functions including nutrient transport and drug efflux. Escherichia coli BamA is an essential component of the OMP β-barrel assembly machinery and a potential novel antibacterial target that has been prop...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Vij, Rajesh, Lin, Zhonghua, Chiang, Nancy, Vernes, Jean-Michel, Storek, Kelly M., Park, Summer, Chan, Joyce, Meng, Y. Gloria, Comps-Agrar, Laetitia, Luan, Peng, Lee, Sophia, Schneider, Kellen, Bevers, Jack, Zilberleyb, Inna, Tam, Christine, Koth, Christopher M., Xu, Min, Gill, Avinash, Auerbach, Marcy R., Smith, Peter A., Rutherford, Steven T., Nakamura, Gerald, Seshasayee, Dhaya, Payandeh, Jian, Koerber, James T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5940829/
https://ncbi.nlm.nih.gov/pubmed/29740124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25609-z
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