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Sex Differences in Rotenone Sensitivity Reflect the Male-to-Female Ratio in Human Parkinson’s Disease Incidence

There is a critical need to include female subjects in disease research; however, in Parkinson’s disease, where the male-to-female incidence is about 1.5-to-1, the majority of preclinical research is conducted in male animals. The mitochondrial complex I inhibitor, rotenone, is selectively toxic to...

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Detaylı Bibliyografya
Yayımlandı:Toxicol Sci
Asıl Yazarlar: De Miranda, Briana R, Fazzari, Marco, Rocha, Emily M, Castro, Sandra, Greenamyre, J Timothy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2019
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592185/
https://ncbi.nlm.nih.gov/pubmed/30907971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz082
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