Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation. Despite emergent evidence that TRPA1 is regulated by the membrane environment, it remains unknown whether this channel...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Startek, Justyna B, Boonen, Brett, López-Requena, Alejandro, Talavera, Ariel, Alpizar, Yeranddy A, Ghosh, Debapriya, Van Ranst, Nele, Nilius, Bernd, Voets, Thomas, Talavera, Karel
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2019
Fag:
Biochemistry and Chemical Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590989/
https://ncbi.nlm.nih.gov/pubmed/31184584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46084
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