Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation. Despite emergent evidence that TRPA1 is regulated by the membrane environment, it remains unknown whether this channel...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Startek, Justyna B, Boonen, Brett, López-Requena, Alejandro, Talavera, Ariel, Alpizar, Yeranddy A, Ghosh, Debapriya, Van Ranst, Nele, Nilius, Bernd, Voets, Thomas, Talavera, Karel
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2019
Schlagworte:
Biochemistry and Chemical Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590989/
https://ncbi.nlm.nih.gov/pubmed/31184584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46084
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