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Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation. Despite emergent evidence that TRPA1 is regulated by the membrane environment, it remains unknown whether this channel...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Startek, Justyna B, Boonen, Brett, López-Requena, Alejandro, Talavera, Ariel, Alpizar, Yeranddy A, Ghosh, Debapriya, Van Ranst, Nele, Nilius, Bernd, Voets, Thomas, Talavera, Karel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590989/
https://ncbi.nlm.nih.gov/pubmed/31184584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.46084
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