TLR9-Activating CpG-B ODN but Not TLR7 Agonists Triggers Antibody Formation to Factor IX in Muscle Gene Transfer

Innate immune signals that promote B cell responses in gene transfer are generally ill-defined. In this study, we evaluate the effect of activating endosomal Toll-like receptors 7, 8, and 9 (TLR7, TLR7/8, and TLR9) on antibody formation during muscle-directed gene therapy with adeno-associated virus...

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Bibliographische Detailangaben
Veröffentlicht in:Hum Gene Ther Methods
Hauptverfasser: Butterfield, John S.S., Biswas, Moanaro, Shirley, Jamie L., Kumar, Sandeep R.P., Sherman, Alexandra, Terhorst, Cox, Ling, Chen, Herzog, Roland W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2019
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590725/
https://ncbi.nlm.nih.gov/pubmed/31140323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2019.013
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