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Amber suppression coupled with inducible surface display identifies cells with high recombinant protein productivity

Cell line development (CLD) for biotherapeutics is a time‐ and resource‐intensive process requiring the isolation and screening of large numbers of clones to identify high producers. Novel methods aimed at enhancing cell line screening efficiency using markers predictive of productivity early in the...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biotechnol Bioeng
Hauptverfasser: Chakrabarti, Lina, Zhuang, Li, Roy, Gargi, Bowen, Michael A., Dall’Acqua, William F., Hawley‐Nelson, Pam, Marelli, Marcello
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6590230/
https://ncbi.nlm.nih.gov/pubmed/30536645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.26892
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