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Local, transient tensile stress on the nuclear membrane causes membrane rupture

Cancer cell migration through narrow constrictions generates compressive stresses on the nucleus that deform it and cause rupture of nuclear membranes. Nuclear membrane rupture allows uncontrolled exchange between nuclear and cytoplasmic contents. Local tensile stresses can also cause nuclear deform...

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Vydáno v:Mol Biol Cell
Hlavní autoři: Zhang, Qiao, Tamashunas, Andrew C., Agrawal, Ashutosh, Torbati, Mehdi, Katiyar, Aditya, Dickinson, Richard B., Lammerding, Jan, Lele, Tanmay P.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Cell Biology 2019
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589786/
https://ncbi.nlm.nih.gov/pubmed/30566037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-09-0604
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