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Local, transient tensile stress on the nuclear membrane causes membrane rupture

Cancer cell migration through narrow constrictions generates compressive stresses on the nucleus that deform it and cause rupture of nuclear membranes. Nuclear membrane rupture allows uncontrolled exchange between nuclear and cytoplasmic contents. Local tensile stresses can also cause nuclear deform...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Zhang, Qiao, Tamashunas, Andrew C., Agrawal, Ashutosh, Torbati, Mehdi, Katiyar, Aditya, Dickinson, Richard B., Lammerding, Jan, Lele, Tanmay P.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589786/
https://ncbi.nlm.nih.gov/pubmed/30566037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-09-0604
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