Hypoxia-induced switch in SNAT2/SLC38A2 regulation generates endocrine resistance in breast cancer

Tumor hypoxia is associated with poor patient outcomes in estrogen receptor-α–positive (ERα(+)) breast cancer. Hypoxia is known to affect tumor growth by reprogramming metabolism and regulating amino acid (AA) uptake. Here, we show that the glutamine transporter, SNAT2, is the AA transporter most fr...

Full description

Saved in:
Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Morotti, Matteo, Bridges, Esther, Valli, Alessandro, Choudhry, Hani, Sheldon, Helen, Wigfield, Simon, Gray, Nicki, Zois, Christos E., Grimm, Fiona, Jones, Dylan, Teoh, Eugene J., Cheng, Wei-Chen, Lord, Simon, Anastasiou, Dimitrios, Haider, Syed, McIntyre, Alan, Goberdhan, Deborah C. I., Buffa, Francesca, Harris, Adrian L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2019
Subjects:
PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6589752/
https://ncbi.nlm.nih.gov/pubmed/31152137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1818521116
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items